Programmable antimicrobial graphene oxide-silver nanoparticle-poly(acrylic acid) hydrogels for smart regenerative medicine

🔗 원문 전체 보기 → Royal Society of Chemistry

요약

RSC Adv., 2026, 16,19542-19555DOI: 10.1039/D5RA09443G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Anika Tabassum Promi, Md. Kaium Hossain, Shaikat Chandra Dey, Aanshi Tiwari, Nusrat…

본문

Programmable antimicrobial graphene oxide-silver nanoparticle-poly(acrylic acid) hydrogels for smart regenerative medicine

* Corresponding authors

a Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka 1000, Bangladesh
E-mail: [email protected]
Tel: (+880) 1680–773–734

b Department of Chemistry, Virginia Tech, Blacksburg, USA

c Department of Chemistry, Bangladesh University of Engineering and Technology, Dhaka 1000, Bangladesh

d Department of Forest Biomaterials, North Carolina State University, Campus Box 8005, Raleigh, NC 27695, USA

e Institute of Advanced Materials, IAAM, Gammalkilsvägen 18, Ulrika 590 53, Sweden

f Department of Community Medicine, Dhaka National Medical College, 53/1 Johnson Road, Dhaka 1100, Bangladesh

g Department of Microbiology, University of Dhaka, Dhaka 1000, Bangladesh

h Department of Microbiology, Noakhali Science and Technology University, Noakhali 3814, Bangladesh

Abstract

Hydrogels with tunable physicochemical properties are being increasingly explored for advanced biomedical applications. In this study, two composite hydrogels were rapidly fabricated through the free radical polymerization of acrylic acid (AA) with the in situ formation of silver nanoparticles (AgNPs) in the presence and absence of graphene oxide (GO). The resulting GO-AgNP-poly(acrylic acid) and AgNP-poly(acrylic acid) hydrogels have been systematically characterized by functional group analysis, crystallinity, thermal stability, elemental analysis, and morphological studies using attenuated total reflectance-infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, energy dispersive spectroscopy, and field-effect scanning electronic microscopy, respectively. Both hydrogels demonstrated pH-switchable swelling–deswelling (on/off) behavior; however, the incorporation of GO provided interfacial channels that enhanced solvent interaction. The in situ-formed AgNPs (∼13 nm) endowed the hydrogels with strong antibacterial and anti-biofilm activity against both Gram-positive and Gram-negative bacterial strains. Cytotoxicity studies confirmed excellent biocompatibility with Vero, HeLa, and BHK-21 cell lines. The synergistic combination of pH-responsiveness, broad-spectrum antimicrobial activity, and cytocompatibility positions these novel composite hydrogels as promising candidates for smart wound healing and tissue engineering applications.