Bioinspired Design of Ca2+ Induced Artificial Signal Transduction Systems: ON/OFF Emitting Bacteria and Excimer-FRET Signalling-Induced Bactericidal Activity

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Chem. Commun., 2026, Accepted ManuscriptDOI: 10.1039/D6CC00258G, CommunicationSubrata Das, Raki Mandal, Rahul Prakash, Sandini P., Sampurna Roy, Pradip K. TarafdarInspired by Ca2+-mediated loop clamping in proteins, we report an artificial signal transducer, …

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Bioinspired Design of Ca2+ Induced Artificial Signal Transduction Systems: ON/OFF Emitting Bacteria and Excimer-FRET Signalling-Induced Bactericidal Activity

Abstract

Inspired by Ca2+-mediated loop clamping in proteins, we report an artificial signal transducer, PyLAD, featuring lithocholic acid linked to aspartic acid moiety for Ca2+ recognition and pyrene unit for signal-reporting, enabling horizontal signal transduction. Ca2+-induced assembly drives reversible ON/OFF signalling, cyan-emitting E. coli, and excimer-FRET signalling-induced inhibition of bacterial growth.