Recent Advances in Point-of-Care Colorimetric Biosensors for Detecting Small Molecule Metabolites

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Chem. Commun., 2026, Accepted ManuscriptDOI: 10.1039/D6CC02166B, Review ArticleZhiqiang Zhu, Zhun Gu, Xinxing Cao, Shanshan Zhang, Shao SuIn the context of the growing need for decentralized diagnostics, colorimetric method emerges as an ideal candidate for p…

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Recent Advances in Point-of-Care Colorimetric Biosensors for Detecting Small Molecule Metabolites

Abstract

In the context of the growing need for decentralized diagnostics, colorimetric method emerges as an ideal candidate for point-of-care (POC) applications due to its distinct advantages, such as simple operation, cost effectiveness, rapid responses, and intuitive results. In recent years, with the rise of nanotechnology and artificial intelligence, intelligent, efficient, and portable colorimetric biosensors have become widespread in many fields. Particularly, these biosensors are also attractive for detecting small molecule metabolites, which serve as critical clinical biomarkers for disease diagnosis and treatment monitoring. Therefore, this review aims to summarize the recent progresses in POC colorimetric biosensors for detecting these metabolites. At first, we introduce the principles and components of POC colorimetric biosensors. Subsequently, we discuss the recent applications of these colorimetric biosensors for the detection of different metabolic biomarkers, such as glucose, uric acid, creatinine and so on. Finally, we conclude a perspective on the future developments of these biosensors.

• This article is part of the themed collection: Nanobiosensors